Lois discovers she has a brother named Patrick and therefore takes the family cross-country to meet him. However, it turns out that he’s in a mental institution, but Lois thinks he’s sane, so she checks him out to live with the Griffins. Meanwhile, Peter starts a Society for the Acceptance of Fat Men. However, the fat men of Quahog are strangled one-by-one.so the Fat Society live in terror. Who is the strangler?
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Lois thinks Stewie is trying to kill her due to his lack of quality time with his father, so she orders Peter to spend more time with Stewie. Meanwhile Chris starts a friendship with Herbert.
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After writing a story for a local magazine, Brian gets a job at The New Yorker. He admitted that he didn’t graduate from college and lost his job. So he went back to college. In the end, he failed.
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After a “wardrobe malfunction” occurs during a live broadcast, the FCC begins to censor all of Peter’s favorite television shows. As a result Peter creates his own TV station “PTV” which broadcasts from of the Griffin home. Peter and Brian create their own edgy programming for the station until the FCC shows up to shut down PTV, and censor all controversial material in Quahog.
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When Chris is supposed to be hazed for a school tradition, he runs off to South America; Peter quickly becomes frustrated by his new job at the beer factory.
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When Peter and the guys decide to go fishing, they end up caught in a storm. Stranded on a desert island, their families fear the worst. Rescued by a cruise ship months later, Peter suprises Lois at home, where he finds out that she has a new husband.
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Peter and Brian’s friendship becomes strained after Brian begins dating Meg’s high school teacher. Peter finds a replacement in new best friend James Woods, who is visiting Quahog because of a suggestion to rename James Woods High School after Martin Luther King Jr.
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Lois fulfills a lifelong dream of being a model. Stewie starts on a multi-level marketing company. Brian in need of cash to buy his de-worming medication agrees to become his salesman.
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Lois’s kleptomania lands her in jail, leaving the Griffin household in a worse state of disarray than usual. In an effort to restore their lives Peter breaks Lois out of jail, only to find themselves fugitives living in “Asian Town” Peter takes up sumo wrestling to pay the bills, until Joe sees Peter on television and goes after them. The family takes refuge in the sewers but it is no use; Joe follows them even down there. A miscalculation sends him hurtling towards his certain doom when Lois saves him… which somehow magically absolves her of her crimes.
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Peter runs up his tab at Mort’s Pharmacy. When he is told he has to pay, he decides to sell Meg to the Goldmans. When Meg finds out that Neil is dating another girl, she becomes jealous and tries to find herself a boyfriend. Meanwhile, Stewie falls in love with Liddane, his new babysitter.
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